Importance of Iron
Iron regulation is critical to red blood cell (RBC) production. In fact, more than two-thirds of the body’s iron content is used in the development of erythroid precursors and mature red cells.3
As illustrated below, iron is required for the normal differentiation and proliferation of erythroid progenitor cells.
Major stages of erythropoiesis4,5
Adapted from Bron et al. Semin Oncol. 2001, and Weiss et al. N Engl J Med. 2005.4,5
Now that you know about the Importance of Iron, learn more about Anemia in CRI.
Iron regulation is critical to red blood cell (RBC) production. In fact, more than two-thirds of the body’s iron content is used in the development of erythroid precursors and mature red cells.3
As illustrated below, iron is required for the normal differentiation and proliferation of erythroid progenitor cells.
Major stages of erythropoiesis4,5
Adapted from Bron et al. Semin Oncol. 2001, and Weiss et al. N Engl J Med. 2005.4,5
- Different steps in the erythropoiesis process are dependent specifically on either iron or erythropoietin,
and lack of either substrate will result in impaired erythrocyte production4 - Erythropoietin is the essential growth factor required for the stimulation of RBC production4,6
- Iron is an essential element for the formation of hemoglobin (Hgb) and development of healthy RBCs4,6
- During erythropoiesis, iron is transported from macrophages by transferrin and incorporated into erythroblasts, precursors of the erythrocyte4,6
Now that you know about the Importance of Iron, learn more about Anemia in CRI.
